NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: L-phenylalanine mustard
L-sarcolysin phenylalanine mustard
phenylalanine nitrogen mustard
US brand name: Alkeran Foreign brand name: Melphalanum
Abbreviation: L-PAM Code name: CB-3025