topoisomerase I/II inhibitor NEV-801
A multi-targeted agent with potential antineoplastic activity. Upon administration, NEV-801 appears to selectively inhibit topoisomerase (Topo) I and II, and activates hypoxia-inducible factor 1 (HIF-1) transcription and the expression of vascular endothelial growth factor (VEGF) mRNA. NEV-801 is also able to overcome multidrug resistance (MDR) 1-mediated resistance.
| Synonym: | TopI/II NEV-801 |
|---|---|
| Code name: | NEV-801 NEV801 |