NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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alvespimycin hydrochloride
The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials using this agent. (NCI Thesaurus)

Abbreviation:17-DMAG HCL
Code name:KOS-1022
Chemical structure:
  • 17-dimethylaminoethylamino-17-demethoxygeldanamycin
  • geldanamycin,17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-,monohydrochloride
  • hydrochloride of (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[[2-(dimethylamino)ethyl]amino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-penten-9-yl carbamate