Prostate Cancer Research Results and Study Updates
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Combination Therapy for Metastatic Prostate Cancer Helps Some Men Live Longer
For men with metastatic castration-resistant prostate cancer, initial treatment with enzalutamide (Xtandi) combined with talazoparib (Talzenna) may help them live longer than getting enzalutamide alone, according to updated results from a large clinical trial.
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Many Men with Metastatic Prostate Cancer Are Not Getting the Recommended Treatments, Study Finds
Many U.S. doctors aren’t using the recommended initial treatments for their patients with hormone-sensitive metastatic prostate cancer, a new study has found. Often, it’s because they aren’t up to date on the latest treatment recommendations or because of side effect concerns.
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Trial Results Support SBRT as a Standard Option for Some Prostate Cancers
In a trial, men who received stereotactic body radiotherapy (SBRT) didn’t have a higher risk of cancer recurrence than men treated with other common radiation therapy regimens that are given over longer periods.
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Enzalutamide Gets Added Approval for Prostate Cancer That Hasn’t Spread
Under a new FDA approval, enzalutamide (Xtandi) can now be used alone, or in combination with leuprolide, to treat people with nonmetastatic prostate cancer that is at high risk of returning after surgery or radiation.
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FDA Approves New Initial Treatment Option for Some Metastatic Prostate Cancers
FDA approved enzalutamide (Xtandi) combined with talazoparib (Talzenna) for metastatic castration-resistant prostate cancer with alterations in any of 12 DNA repair genes. The drug combination, which blocks both DNA repair activities and hormones that fuel cancer growth, was more effective than the standard treatment in a large clinical trial.
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Is a Genomic Test Better at Finding Aggressive Prostate Cancer?
The Decipher genomic test found high-risk prostate cancer even when conventional tests said the tumors were lower risk. This discrepancy appeared to happen more frequently for African-American men.
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Active Surveillance for Low-Risk Prostate Cancer Continues to Rise
Men diagnosed with low-risk prostate cancer are increasingly opting against immediate treatment and choosing active surveillance instead, a new study finds. In fact, rates of active surveillance more than doubled between 2014 and 2021.
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Darolutamide Extends Survival for Some People with Metastatic Prostate Cancer
Adding darolutamide (Nubeqa) to ADT and docetaxel (Taxotere) can improve how long men with hormone-sensitive metastatic prostate cancer live without causing more side effects, results from the ARASENS trial show.
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Shorter, More Intensive Radiation Safe after Surgery for Prostate Cancer
Many with prostate cancer can safely receive shorter, higher-dose radiation therapy after surgery, a new study has found. The approach, called HYPORT, didn’t harm patients’ quality of life compared with the standard radiation approach, trial finds.
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For Advanced Prostate Cancer, Radiopharmaceutical Improves Survival
A drug called Lu177-PSMA-617 may be a new option for treating advanced prostate cancer. In a large clinical trial, adding the drug—a type of radiopharmaceutical—to standard treatments improved how long participants lived.
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Hormone Therapy for Prostate Cancer? A Genetic Test Could Help Decide
For some men with prostate cancer, a genetic biomarker test called Decipher may help predict if their cancer will spread elsewhere in the body. The test could help determine whether hormone therapy, which can cause distressing side effects, is needed.
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Relugolix Approval Expected to Alter Treatment for Advanced Prostate Cancer
FDA’s recent approval of relugolix (Orgovyx) is expected to affect the treatment of men with advanced prostate cancer. A large clinical trial showed that relugolix was more effective at reducing testosterone levels than another common treatment.
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With Two FDA Approvals, Prostate Cancer Treatment Enters the PARP Era
FDA has approved olaparib (Lynparza) and rucaparib (Rubraca) to treat some men with metastatic prostate cancer. The PARP inhibitors are approved for men whose cancers have stopped responding to hormone treatment and have specific genetic alterations.
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PSMA PET-CT Accurately Detects Prostate Cancer Spread, Trial Shows
For some men with prostate cancer at high risk of spreading, a large clinical trial shows an imaging method called PSMA PET-CT is more likely to detect metastatic tumors than the standard imaging approach used in many countries.
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Testing with Combined Biopsy Method Improves Prostate Cancer Diagnosis in NCI Study
Testing for prostate cancer with a combined biopsy method led to more accurate diagnosis and prediction of the course of the disease in an NCI study. The method is poised to reduce the risk of prostate cancer overtreatment and undertreatment.
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VA Study Finds No Disparities in Prostate Cancer Deaths with Equal Access to Care
In the Veterans Affairs health care system—where all patients have equal access to care—African American men did not appear to have more-aggressive prostate cancer when diagnosed or a higher death rate from the disease than non-Hispanic white men.
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More Treatment Options Emerging for Some Men with Metastatic Prostate Cancer
In two large clinical trials, the drugs enzalutamide (Xtandi) and apalutamide (Erleada), respectively, combined with the androgen deprivation therapy, improved the survival of men with metastatic prostate cancer that still responds to hormone-suppressing therapies.
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Prostate Cancer Prevention and Finasteride: A Conversation with NCI’s Dr. Howard Parnes
The Prostate Cancer Prevention Trial showed that finasteride can reduce the risk of prostate cancer, but might increase the risk of aggressive disease. NCI’s Howard Parnes talks about subsequent findings and what they mean for men aged 55 and older.
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Darolutamide Delays the Spread of Some Prostate Cancers
The investigational drug darolutamide can help delay the spread of prostate cancer in some men with the disease, a recent clinical trial shows. In addition, the drug caused fewer side effects than similar prostate cancer drugs.
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African American Men More Likely to Die from Low-Grade Prostate Cancer
For African American men, the risk of dying from low-grade prostate cancer is double that of men of other races, a new study has found. But, despite the increase, the risk is still small.
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Aggressive Prostate Cancer Subtype More Common Than Expected
Researchers have found that men with advanced prostate cancer may be more likely than previously thought to develop a more aggressive form of the disease. The subtype, called t-SCNC, was linked with shorter survival than other subtypes.
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NIH and Prostate Cancer Foundation launch large study on aggressive prostate cancer in African-American men
RESPOND is the largest coordinated study on biological and non-biological factors associated with aggressive prostate cancer in African-American men. The study is an effort to learn why these men disproportionally experience aggressive disease.
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Take with Food: Study Tests Lowering Dose of Prostate Cancer Drug
In a small clinical trial, researchers compared the efficacy of a much lower dose of the cancer drug abiraterone (Zytiga) taken with a low-fat breakfast with a full dose taken on an empty stomach, as directed on the drug’s label.
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FDA Approves Apalutamide for Some Men with Prostate Cancer
In the trial that led to the approval, apalutamide (Erleada) delayed cancer metastasis for men with prostate cancer that is resistant to androgen deprivation therapy.
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Molecular Switch Links High-Fat Diet to Prostate Cancer Metastasis
A new study in mice has revealed a molecular link between a high-fat diet and the growth and spread of prostate cancer. The findings, the study leaders believe, raise the possibility that changes in diet could potentially improve treatment outcomes in some men.
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Abiraterone Approved for Earlier Use in Men with Metastatic Prostate Cancer
The Food and Drug Administration (FDA) has expanded the approval of abiraterone (Zytiga®) for men with prostate cancer. The agency approved abiraterone, in combination with the steroid prednisone, for men with metastatic prostate cancer that is responsive to hormone-blocking treatments (also known as castration-sensitive) and is at high risk of progressing.