Nivolumab

FDA Approval for Nivolumab for Urothelial Carcinoma

FDA Approval for Nivolumab for Head and Neck Cancer

FDA Approval for Nivolumab for Classical Hodgkin Lymphoma

FDA Approval for Nivolumab for Renal Cell Carcinoma

FDA Approval for Nivolumab for Non-Squamous Non-Small Cell Lung Cancer

FDA Approval for Nivolumab with Ipilimumab for Melanoma

FDA Approval for Nivolumab for Squamous Non-Small Cell Lung Cancer

FDA Approval for Nivolumab for Melanoma

Use in Cancer

Nivolumab is approved to be used alone or with other drugs to treat:

• Classical Hodgkin lymphoma that has gotten worse after an autologous stem cell transplant and treatment with brentuximab vedotin.
• Melanoma that cannot be removed by surgery or that has metastasized (spread to other parts of the body).
  • It is used with ipilimumab in patients whose cancer does not have a certain BRAF gene mutation.
  • It is used alone in patients whose disease got worse after being treated with ipilimumab and, if their cancer had a certain BRAF gene mutation, with a drug called a BRAF inhibitor.
• Non-small cell lung cancer that has metastasized. It is used in patients whose disease got worse during or after treatment with platinum chemotherapy. Patients whose cancer has certain gene mutations should receive nivolumab only if their disease got worse after treatment with FDA-approved therapy for the gene mutations.
• Renal cell carcinoma (a type of kidney cancer) that is advanced. It is used in patients who have already received angiogenesis inhibitor therapy.
• Squamous cell carcinoma of the head and neck that has metastasized or recurred (come back) in patients whose disease got worse during or after treatment with platinum chemotherapy.
• Urothelial carcinoma (a type of bladder cancer) that is locally advanced or has metastasized. It is used in patients whose disease got worse during or after treatment with platinum chemotherapy.

Nivolumab is also being studied in the treatment of other types of cancer.

More About Nivolumab

Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Nivolumab - A lay language summary of important information about this drug that may include the following:

• warnings about this drug,
• what this drug is used for and how it is used,
• what you should tell your doctor before using this drug,
• what you should know about this drug before using it,
• other drugs that may interact with this drug, and
• possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Research Results and Related Resources

FDA Approves Nivolumab for Bladder Cancer

With Immunotherapy, Glimmers of Progress Against Glioblastoma

Lung Cancer Precision Medicine Trials: Adapting to Progress

Nivolumab-Based Treatments Delay Progression of Advanced Melanoma

Nivolumab Improves Overall Survival in Patients With Metastatic Melanoma Without a BRAF Mutation

New Therapies Are Changing the Outlook for Advanced Melanoma

Targeted Cancer Therapies

Clinical Trials Accepting Patients

Find Clinical Trials for Nivolumab - Check for trials from NCI's list of cancer clinical trials now accepting patients.