Translational and Basic Science Research in Early Lesions (TBEL)
The overarching goal of the TBEL Program is to understand the biological and pathophysiological mechanisms driving or restraining pre-cancers and early cancers and to facilitate biology-backed precision prevention approaches.
Towards this goal, TBEL supports multi-disciplinary research centers that pursue studies integrating basic and translational research in an iterative manner to investigate the causal relationships and interactions of an early lesion, its microenvironment, and host-systemic factors as “co-organizers” of tumor initiation (or suppression) and malignant progression in conjunction with the clinical characteristics.
The TBEL Program spans a broad range of tumor sites (with associated clinical samples), biological models, and diverse targets to identify unique and/or common pathways of indolence or aggressiveness. Collectively, TBEL seeks to promote a deeper understanding of early lesions, their microenvironments, and reciprocal interactions that drive early lesion fate and clinical outcomes.