Skip to main content

Translational and Basic Science Research in Early Lesions (TBEL)

Human breast cancer cells.

Credit: National Cancer Institute

The overarching goal of the TBEL Program is to understand the biological and pathophysiological mechanisms driving or restraining pre-cancers and early cancers and to facilitate biology-backed precision prevention approaches.

Towards this goal, TBEL supports multi-disciplinary research centers that pursue studies integrating basic and translational research in an iterative manner to investigate the causal relationships and interactions of an early lesion, its microenvironment, and host-systemic factors as “co-organizers” of tumor initiation (or suppression) and malignant progression in conjunction with the clinical characteristics.

The TBEL Program spans a broad range of tumor sites (with associated clinical samples), biological models, and diverse targets to identify unique and/or common pathways of indolence or aggressiveness. Collectively, TBEL seeks to promote a deeper understanding of early lesions, their microenvironments, and reciprocal interactions that drive early lesion fate and clinical outcomes.

  • Updated:

If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Translational and Basic Science Research in Early Lesions (TBEL) was originally published by the National Cancer Institute.”