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Cancer Currents: An NCI Cancer Research Blog

A blog featuring news and research updates from the National Cancer Institute.

An illustrated banner to represent NCI's Cancer Currents research news blog. The design features interconnected scenes: a patient receiving care, a researcher in a lab, a tumor model, a laptop and mobile device displaying research articles, fitness activity, a clinical setting, and a researcher giving a scientific presentation. The background showcases rolling hills and abstract buildings.
  • A pair of hands clasping the hands of another person.
    • By Elia Ben-Ari

    Black and Hispanic patients nearing the end of life are less likely than White patients to get opioids needed to control their cancer pain, a new study shows. Black patients were also more likely than White patients to undergo urine tests that screen for drugs.

  • An illustration showing two cancer cells side by side with different amounts of HER2 on its surface.
    • By Sharon Reynolds

    FDA approved tucatinib (Tukysa) with trastuzumab (Herceptin) to treat HER2-positive advanced colorectal cancer. The approval was based on the MOUNTAINEER trial, in which nearly 40% of participants’ tumors shrank after receiving the drug combination.

  • Woman (NCI Director Dr. Monica Bertagnolli) with dark hair wears a brown jacket over a patterned top and smiles at the camera.
    • By Monica Bertagnolli, M.D.

    NCI Director Dr. Monica Bertagnolli reflects on the tremendous progress made in cancer research over the past 3 decades, important opportunities that lie ahead, and the need for coordinated, all-of-society collaboration to end cancer as we know it for everyone.

  • Illustrations of two next-generation CAR T cells
    • By Sharon Reynolds

    Two research teams have developed ways of overcoming barriers that have limited the effectiveness of CAR T-cell therapies, including engineering ways to potentially make them effective against solid tumors like pancreatic cancer and melanoma.

  • A cartoon depicting the idea of a doctor speaking with another doctor via video on a cell phone.
    • By Carmen Phillips

    An NCI-funded clinical trial has shown that treatment-related early deaths in people with a rare leukemia can be dramatically reduced. How did they do it? In part, by establishing a help desk staffed by experts in treating APL.

  • A health provider holding a stethoscope to a woman's chest.
    • By Shana Spindler

    FDA has approved zanubrutinib (Brukinsa) for chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) based on results from two clinical trials. In both trials, the drug, which blocks a protein called BTK, was more effective and caused fewer side effects than other treatments.

  • Illustration depicting mechanism of action of blinatumomab (Blincyto)
    • By Linda Wang

    The immunotherapy drug blinatumomab (Blincyto) extends life for people with acute lymphoblastic leukemia who are in remission, even those with no signs of disease after initial treatment, a trial has found.

  • A photo of Shayla Johnson and her nearly 1-year-old son Ronin.
    • By Edward Winstead

    Many young women who are diagnosed with early-stage breast cancer want to become pregnant in the future. New research suggests that these women may be able to pause their hormone therapy for up to 2 years as they try to get pregnant without raising the risk of a recurrence in the short term.

  • Cancers Associated with Drinking Alcohol Infographic
    • By Anna Hopkins

    A study confirmed that most US adults aren’t aware of the link between alcohol consumption and cancer. Even among those surveyed who were aware, some believed risk varies by the type of alcohol.

  • Two microscopic images are shown, each displaying complex cellular structures and tissues. The top image features a network of cells and fibers mostly in blue, green, and purple, with some areas highlighted in pink. The bottom image also shows a dense arrangement of cells and fibers with similar staining, but presents a different pattern and distribution of the colored elements.
    • By Elia Ben-Ari

    An experimental drug, MRTX1133, shrank tumors or halted their growth in several mouse models of human pancreatic cancer with KRAS G12D mutations, a new study shows. The models included one that is genetically engineered to closely mimic the human disease.

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