2022 - Cancer Currents Blog
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In people with cancer treated with immune checkpoint inhibitors, a rare, but often fatal, side effect is inflammation in the heart, called myocarditis. Researchers have now identified a potential chief cause of this problem: T cells attacking a protein in heart cells called α-myosin.
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To mark her first year at NCI, Dr. Katrina Goddard lays out her research priorities for the Division of Cancer Control and Population Sciences and outlines key opportunities for reducing the burden of cancer. These future directions and priorities are outlined in the division’s 2022 Overview and Highlights report.
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Researchers have modified a chemo drug, once abandoned because it caused serious gut side effects, so that it is only triggered in tumors but not normal tissues. After promising results in mice, the drug, DRP-104, is now being tested in a clinical trial.
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Based on an NCI-sponsored clinical trial conducted by the Children’s Oncology Group, FDA has approved the drug brentuximab vedotin (Adcetris) in combination with chemotherapy for some children and adolescents with Hodgkin lymphoma.
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An NCI study in mice has identified a drug combination that may help treat children with rhabdomyosarcoma. But one of the drugs, ganitumab, is no longer being made. Based on the study's promising results, the NCI researchers who led the study want to test the combination in humans.
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A new study suggests that people with obesity who had bariatric surgery had a much lower risk of five common cancers that aren’t related to hormone levels, including lung, colorectal, and esophageal cancer.
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In a large clinical trial, a condensed course of radiation therapy was as effective and safe as a longer standard course for those with higher-risk early-stage breast cancer who had a lumpectomy. This shorter radiation course makes treatment less of a burden for patients.
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In a review of 33 cancer screening guidelines, researchers have found that many don’t adequately capture the potential harms of cancer screening. Providing information on harms is critical so people can have informed discussions about screening with their health care providers, the researchers noted.
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A study in India has found that an ultra-low dose of the immunotherapy drug nivolumab (Opdivo) helped people with advanced head and neck cancer live longer. Because the dose is 6% of what’s typically used in the United States and Europe, it is potentially more affordable.
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In a new study, researchers showed that cancer cells with mutations in the IDH1 gene release large amounts of a metabolite called D-2HG. Once outside of the cells, D-2HG acts like force field by neutralizing nearby immune cells.