eflornithine hydrochloride
View Patient InformationThe hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells.
| Synonym: | 2-difluoromethylornithine hydrochloride alpha-difluoromethylornithine hydrochloride eflornithine HCl |
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| US brand name: | Iwilfin Vaniqa |
| Code name: | MDL 71782 RMI-71782 |
| Chemical structure: | 2-(difluoromethyl)-DL-ornithine hydrochloride, monohydrate 2-difluoromethyl-dl-ornithine, monohydrochloride, monohydrate |