leuprolide acetate
View Patient InformationThe acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.
| Synonym: | leuprorelin acetate |
|---|---|
| US brand name: | Eligard Lupron Depot |
| Foreign brand name: | Carcinil Depo-Eligard Enanton Enantone Enantone-Gyn Ginecrin Leuplin Lucrin Lucrin Depot Luprodex Depot Lutrate Procren Procrin Prostap Trenantone Uno-Enantone |
| Abbreviation: | LEUP |
| Code name: | A-43818 Abbott 43818 TAP-144 |
| Chemical structure: | 6-D-leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (pig) monoacetate 6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide luteinizing hormone-releasing factor (pig) monoacetate |