hydroxyurea
View Patient InformationA monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.
| Synonym: | HYD Hydroxycarbamide Hydurea |
|---|---|
| US brand name: | Droxia Hydrea |
| Foreign brand name: | Litalir Onco-Carbide Oxeron Syrea |
| Abbreviation: | HU |
| Code name: | SQ 1089 SQ-1089 WR 83799 |
| IND number: | 38558 7179 9235 937 |
| NSC code: | 32065 |