NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-CD3/anti-GPRC5D bispecific monoclonal antibody JNJ-64407564
A bispecific humanized monoclonal antibody against human CD3, a T-cell surface antigen, and human G-protein coupled receptor family C group 5 member D (GPRC5D), a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD3/anti-GPRC5D bispecific monoclonal antibody JNJ-64407564 binds to both CD3 on T cells and GPRC5D expressed on certain tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against GPRC5D-expressing tumor cells. GPRC5D is overexpressed on certain tumors, such as multiple myeloma, while minimally expressed on normal, healthy cells, and plays a key role in tumor cell proliferation. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:GPRC5D x CD3 bispecific antibody JNJ-64407564
GPRC5D x CD3 duobody antibody JNJ-64407564
GPRC5D/CD3 duobody antibody JNJ-64407564
humanized GPRC5D x CD3 duobody antibody JNJ-64407564
Code name:JNJ 64407564
JNJ64407564
JNJ-64407564