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cladribine

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A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity.
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Synonym:cladribina
Foreign brand name:Leustat
Leustatine
Abbreviation:2-CdA
2CDA
CdA
Code name:RWJ-26251
Chemical structure:2-chloro-2-deoxyadenosine
2-chlorodeoxyadenosine
IND number:37433
NSC code:105014-F
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