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leuprolide acetate

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The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.
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Synonym:leuprorelin acetate
US brand name:Eligard
Lupron Depot
Foreign brand name:Carcinil
Depo-Eligard
Enanton
Enantone
Enantone-Gyn
Ginecrin
Leuplin
Lucrin
Lucrin Depot
Luprodex Depot
Lutrate
Procren
Procrin
Prostap
Trenantone
Uno-Enantone
Abbreviation:LEUP
Code name:A-43818
Abbott 43818
TAP-144
Chemical structure:6-D-leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (pig) monoacetate
6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide luteinizing hormone-releasing factor (pig) monoacetate
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