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lomustine

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A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier.
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Synonym:Lomustinum
US brand name:Gleostine
Foreign brand name:Belustin
Belustine
Cecenu
Citostal
Lomeblastin
Lucostin
Lucostine
Prava
Abbreviation:CCNU
Acronym:CCNU
Code name:RB-1509
WR-139017
Chemical structure:1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-
chloroethylcyclo-hexylnitrosourea
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
IND number:4595
NSC code:79037
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