lomustine
View Patient InformationA nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier.
| Synonym: | Lomustinum |
|---|---|
| US brand name: | Gleostine |
| Foreign brand name: | Belustin Belustine Cecenu Citostal Lomeblastin Lucostin Lucostine Prava |
| Abbreviation: | CCNU |
| Acronym: | CCNU |
| Code name: | RB-1509 WR-139017 |
| Chemical structure: | 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea 1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl- chloroethylcyclo-hexylnitrosourea N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea |
| IND number: | 4595 |
| NSC code: | 79037 |