mechlorethamine hydrochloride
View Patient InformationThe hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties.
| Synonym: | chlorethamine HCl chlorethamine hydrochloride chlorethazine hydrochloride chlormethine hydrochloride chloromethine HCl HN 2 hydrochloride mechlorethamine HCl mustargen HCl mustargen hydrochloride mustine N-Lost |
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| US brand name: | Valchlor |
| Foreign brand name: | Caryolysine Cloramin Erasol Mustine Hydrochloride Onco-Cloramin |
| Code name: | WR-147650 |
| Chemical structure: | bis(2-chloroethyl)methylamine hydrochloride ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl hydrochloride methylbis(beta-chloroethyl)amine hydrochloride |
| NSC code: | 762 |