pertuzumab
View Patient InformationA humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis.
| Synonym: | 2C4 2C4 antibody monoclonal antibody 2C4 omnitarg pertuzumab biosimilar BCD-178 pertuzumab biosimilar EG1206A pertuzumab biosimilar HLX11 pertuzumab biosimilar HS627 pertuzumab biosimilar TQB2440 rhuMAb-2C4 rhuMAb2C4 |
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| US brand name: | Perjeta |
| Abbreviation: | MOAB 2C4 |
| Code name: | BCD-178 EG1206A HLX11 HS627 RO4368451 TQB 2440 TQB-2440 TQB2440 TQB2440 |
| Chemical structure: | immunoglobulin G1, anti-(human V (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer |