tofacitinib topical cream

A topical cream formulation containing the Janus kinase (JAK) inhibitor tofacitinib, with potential immunomodulatory and anti-inflammatory activities. Upon topical administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha (IFN-a) and -beta (IFN-b), and may prevent both an inflammatory response and the inflammation-induced damage caused by certain diseases. JAK are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation.