NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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methotrexate

An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for using this agent. ()

Synonym:	alpha-methopterin amethopterin methotrexate methylaminopterin Methotrexatum methylaminopterin Metotrexato
US brand name:	Abitrexate Folex Folex PFS Methotrexate LPF Mexate Mexate-AQ Rheumatrex Trexall
Foreign brand name:	Brimexate Emtexate Emthexat Emthexate Farmitrexat Fauldexato Lantarel Ledertrexate Lumexon Maxtrex Medsatrexate Metex Methoblastin Metrotex Novatrex Texate Tremetex Trexeron Trixilem
Abbreviation:	MTX
Code name:	CL-14377 WR-19039
Chemical structure:	4-amino-10-methylfolic acid 4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid