CUPA case in which cancer cells are found in the body, but the place where the cells first started growing (the origin or primary site) cannot be determined. Also called cancer of unknown primary origin and carcinoma of unknown primary.More InformationCarcinoma of Unknown PrimaryEnlarge this image in new windowIn cancer of unknown primary, cancer cells have spread in the body but the place where the primary cancer began is not known.Search NCI's Dictionary of Cancer TermsStarts withContainsBrowse:ABCDEFGHIJKLMNOPQRSTUVWXYZ#