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FH gene

(… jeen)
A gene that makes an enzyme that helps cells in the body use oxygen and make energy. Mutated (changed) forms of the FH gene may cause cells to lose the ability to use oxygen. This may increase the growth of some cells, including abnormal cells and cancer cells. The mutated FH gene has been found in an inherited condition called hereditary leiomyomatosis and renal cell cancer (HLRCC). Patients with HLRCC have an increased risk of kidney cancer and tumors in the skin and uterus. Also called fumarate hydratase gene.
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