NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,389 terms related to cancer and medicine.

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human epidermal growth factor receptor 2 negative
(HYOO-mun eh-pih-DER-mul grothe FAK-ter reh-SEP-ter … NEH-guh-tiv)
Describes cancer cells that do not have a large amount of a protein called HER2 on their surface. In normal cells, HER2 helps to control cell growth. Cancer cells that are human epidermal growth factor receptor 2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface. Checking for the amount of HER2 on some types of cancer cells may help plan treatment. These cancers include breast, bladder, ovarian, pancreatic, and stomach cancers. Also called HER2 negative.