NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,487 terms related to cancer and medicine.

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Li-Fraumeni syndrome
(lee-FRAH-meh-nee SIN-drome)
A rare, inherited disorder that is caused by mutations (changes) in the TP53 gene. Having Li-Fraumeni syndrome increases the risk of developing many types of cancer. Cancers often develop at an early age, and more than one type of cancer may occur in the same person. Li-Fraumeni syndrome is a type of hereditary cancer syndrome. Also called LFS.