nonsense variantListen to pronunciation(NON-sens VAYR-ee-unt)A change in the DNA sequence of a gene that signals the cell to stop making the protein before it is complete. This results in a shorter protein that may not function. Also called nonsense mutation.More InformationNonsense Mutation (National Human Genome Research Institute)Search NCI's Dictionary of Cancer TermsStarts withContainsBrowse:ABCDEFGHIJKLMNOPQRSTUVWXYZ#