NucyntaListen to pronunciation(noo-SIN-tuh)A drug used to treat moderate to severe pain. It binds to opioid receptors and other molecules in the central nervous system. Nucynta is a type of opioid and a type of analgesic agent. Also called tapentadol hydrochloride.Search NCI's Dictionary of Cancer TermsStarts withContainsBrowse:ABCDEFGHIJKLMNOPQRSTUVWXYZ#