pevonedistat
(PEH-voh-NEH-dih-stat)
A substance being studied in the treatment of some types of cancer. Pevonedistat blocks an enzyme called NEDD8-activating enzyme (NAE), which is involved in cell division. Blocking this enzyme may help keep cancer cells from growing and may kill them. Pevonedistat is a type of NAE inhibitor and a type of targeted therapy.