NCI Dictionary of Cancer Terms
The NCI Dictionary of Cancer Terms features 8,442 terms related to cancer and medicine.
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- phase I clinical trial
- listen (fayz … KLIH-nih-kul TRY-ul)
- The first step in testing a new treatment in humans. A phase I clinical trial tests the safety, side effects, best dose, and timing of a new treatment. It may also test the best way to give a new treatment (for example, by mouth, infusion into a vein, or injection) and how the treatment affects the body. The dose is usually increased a little at a time in order to find the highest dose that does not cause harmful side effects. Phase I clinical trials usually include only a small number of patients who have not been helped by other treatments. Sometimes they include healthy volunteers. Also called phase 1 clinical trial.