sotorasib
(SOH-toh-RA-sib)
A drug used alone to treat adults with non-small cell lung cancer that has spread or cannot be removed by surgery, and with panitumumab to treat colorectal cancer that has spread. It is used in patients who have a certain mutation (change) in the KRAS gene and whose cancer was treated with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Sotorasib blocks a protein (KRAS p.G12C) made by the mutated KRAS gene, which may help keep cancer cells from growing and may kill them. It is a type of targeted therapy. Also called Lumakras.