systemic sclerosisListen to pronunciation(sis-TEH-mik skleh-ROH-sis)A disease that is marked by hardening and thickening of skin, connective tissue that surrounds other tissues and organs, and blood vessels. Also called systemic scleroderma.Search NCI's Dictionary of Cancer TermsStarts withContainsBrowse:ABCDEFGHIJKLMNOPQRSTUVWXYZ#