UltramListen to pronunciation(UL-tram)A drug used to treat moderate to severe pain in adults. It binds to opioid receptors in the central nervous system. Ultram is a type of analgesic agent and a type of opioid. Also called tramadol hydrochloride.Search NCI's Dictionary of Cancer TermsStarts withContainsBrowse:ABCDEFGHIJKLMNOPQRSTUVWXYZ#