NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,331 terms related to cancer and medicine.

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wild-type KRAS gene
(… KAY-ras jeen)
A term used to describe a gene called KRAS when it is found in its natural, non-mutated (unchanged) form. The KRAS gene makes a protein called KRAS, which is involved in cell signaling pathways that control cell growth, cell maturation, and cell death (apoptosis). Mutated (changed) forms of the KRAS gene have been found in some types of cancer, including non-small cell lung cancer (NSCLC), colorectal cancer, and pancreatic cancer. Knowing whether a patient’s tumor has a wild-type or mutated KRAS gene may help plan cancer treatment.