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Metastasis Research Network (MetNet)

Metastasis Research Network (MetNet) Image

Metastasis Research Network (MetNet) 

Credit: DCB

Understanding the spectrum of complex metastatic processes is important to the development of a comprehensive and cohesive understanding of cancer metastasis. The Metastasis Research Network (MetNet) supports several U54 Specialized Centers (RFA-CA-20-029). These collaborative, multidisciplinary projects focus on several themes of the metastatic process and utilize integrative systems-level approaches.

The MetNet will advance the understanding of metastasis as a non-linear, dynamic, and emergent process and promote advances in mechanistic understanding of early dissemination, cellular and physical microenvironment crosstalk, dormancy, and mechanisms of responses by metastatic cells to therapies.

MetNet News and Publications

A new MetNet U54 grant was awarded in Fall 2022. The NYULH Metastasis Research Network Center, led by Dr. Eva Hernando and Dr. Iman Osman, aims to build an in-depth transcriptional and cellular map of tumor microenvironment interactions that regulate early dissemination in melanoma. This work leverages the expertise of collaborative researchers, novel mouse models of melanoma progression, and clinically annotated patient samples. 

Upcoming and Past Meetings

September 24, 2021 - MetNet Center Introductions

December 2, 2021 - MetNet Kickoff Meeting

Funded Projects

Institution Principal Investigator(s) Project Title
Stanford University Christina Curtis Evolutionary dynamics and microenvironmental determinants of metastatic breast cancer
Massachusetts Institute of Technology Roger Kamm, Vivek Shenoy Mechanical determinants of organ-selective metastatic colonization, dormancy, and outgrowth
Stanford University Melanie Hayden Gephart Deconvolution and interruption of the cancer-neuro-immune axis facilitating brain metastases
Rockefeller University Sohail Tavazoie Center for systems-level study of metastasis
New York University School of Medicine Eva Hernando, Iman Osman NYULH Metastasis Research Network Center (NYULH MetNet Center)
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