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Oncology Models Forum (OMF)

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Oncology Models Forum

The Oncology Models Forum (OMF) was launched by the NCI in 2014 to fund research into advancing standard practices for modeling human cancers in mice and to facilitate collaborations, data sharing, and harmonization of mouse models. In 2016, the Funding Opportunity Announcement (FOA) was expanded to all mammalian model systems (PAR-16-059) and has been re-issued in 2017 (PAR-17-245), 2020 (PAR-20-131), and 2023 (PAR-23-281).

Unlike many hypothesis-driven and mechanistic R01 projects, this program is devoted to ensuring mammalian models used for translational research questions are appropriate for those purposes and the models provide reliable and informative data for patient benefit. The OMF now includes a range of models including canine, porcine, organoid, and cell line models, in addition to many diverse mouse model systems.

OMF News and Highlights

OMF Scientist Highlights: Drs. Wen Xue, Vishnu Hosur, and Ming Chen

Dr. Wen Xue is an Associate Professor at the UMass Chan Medical School who is generating and characterizing animal models of cancer using CRISPR-based genome editing techniques. 

His team developed dual prime editing-based precise deletion and repair. This technique enables large genomic deletion coupled with insertion. The study demonstrates the potential applications of prime editing to model complex genomic alterations in cancer.

The Xue laboratory also applies in vivo delivery of CRISPR in somatic organs to rapidly create new mouse models of cancer, including aggressive liver and lung cancer.

Dr. Vishnu Hosur is a Research Scientist at the Jackson Laboratory who utilizes advanced genetic engineering technology, including CRISPR/Cas9 and Bxb1 recombinases, to study complex cancer biology using mouse models.

His team generated new mouse models with human neutrophils—or humanized mice—to study the role of neutrophils in cancer. 

The Hosur lab also investigates the ways that mice respond to different methods of gene disruption, which have significant implications for the application of genome editing in both basic research and clinical practice.

Dr. Ming Chen is an Associate Professor at Duke University School of Medicine whose laboratory developed a series of genetically engineered mouse models that mimic the development of human prostate cancer, ranging from localized to metastatic prostate cancer.

His team used these models to dissect disease mechanisms and perform preclinical studies to discover and validate therapeutic targets.

The Chen laboratory is also creating conditional mouse alleles that enable the development of new cancer models that recapitulate human cancers associated with large chromosomal deletions, including prostate cancer.

OMF Funding Opportunity

PAR-23-281 : Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)

OMF Meetings

May 16, 2024 
Oncology Models Forum Spring Seminar (Virtual)

December 5-6, 2023
Oncology Models Forum Annual Meeting 

July 23, 2023 
Oncology Models Forum Summer Seminar

March 15-16, 2022 
Oncology Models Forum Annual Meeting

December 9, 2021
Oncology Models Forum Fall Seminar

July 27, 2021
Oncology Models Forum Summer Seminar

March 30-31, 2021
Oncology Models Forum Annual Meeting (Virtual) 

January 30, 2020
NCI Oncology Models Forum Meeting (NCI Shady Grove)

November 8, 2018
NCI Oncology Models Forum Meeting (University of California, San Francisco)

September 18-19, 2017
Immune Interventions in Oncology: A Think Tank on Modeling Opportunities using Mice and Human Specimens (NCI Shady Grove)

  • Human Cancer Models Initiative (HCMI) Catalog – Resource of patient-derived next-generation cancer models developed by HCMI, which is an international collaboration between NCI, Cancer Research UK, the Wellcome Sanger Institute, and Hubrecht Organoid Technology
  • NCI Mouse Repository NCI-funded resource for mouse cancer models and associated strains
  • Oncology Model Fidelity Score – Uses the Hallmarks of Cancer to compare cancer animal models to human cancer
  • Single R – Analyzes cellular heterogeneity from single-cell RNA sequencing data
  • Xcell – Analyzes cellular heterogeneity from bulk gene expression data

Contacts for the OMF

For additional information about the OMF, please contact Dr. Joanna Watson or Dr. Christine Nadeau

Funded Projects

Institution Principal Investigator(s) Project Title
University of California, San Francisco Mary Helen Barcellos-Hoff Definition of Immune Infiltrate Phenotype and DNA Damage Response Deficits Across Diverse Murine Mammary Carcinomas 
Broad Institute, Inc. Jesse Samuel Boehm Rapid ex vivo biosensor cultures to assess dependencies in gastroesophageal cancer 
Emory University  Nicholas M. Boulis, Peter Canoll Lentiviral-Induced Swine Model of Spinal Cord Glioma 
Rockefeller University Stylianos Bournazos Novel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based Therapeutics 
Northwestern University  Daniel J. Brat Modeling the Glioblastoma Microenvironment to Uncover Progression Mechanisms and Therapeutic Targets 
University of Nebraska Medical Center Mark A. Carlson Development and Application of a Porcine Model of Pancreatic Cancer 
UT Southwestern Medical Center Diego H. Castrillon Polymerase-Mediated Ultramutagenesis and Carcinogenesis in Mice 
Beth Israel Deaconess Medical Center Alain Charest, Vassiliki A. Boussiotis, Roel GW Understanding the cellular and functional changes in the immune tumor microenvironment of glioblastoma during progression and treatments
Beth Israel Deaconess Medical Center Alain Charest, Vassiliki A. Boussiotis

Advancing Treatment Outcomes in Malignant Glioma by Integrating Immunotherapy and Standard of Care Using Genetically Engineered Mice that Recapitulate Molecular Feature of Human Glioma 

Duke University Ming Chen Engineering Large Chromosomal Deletions in Mice to Advance Precision Oncology
Mayo Clinic Arizona Marta Chesi Credentialing a Genetically Engineered Clinically-Relevant Mouse Model of Multiple Myeloma 
Mayo Clinic Arizona Marta Chesi, Peter Leif Bergsagel Preclinical optimization of BCMA directed T cell therapy
University of Michigan Kathleen R. Cho Modeling Factors Associated with Risk of High-Grade Serous Carcinoma in Mice 
Weill Medical College of Cornell University Lukas Edward Dow In Vivo Base Editing for Precision Oncology Models 
University of Colorado Denver Patricia Ernst, Terry Fry Escape from CAR T surveillance through lineage plasticity
Washington University Ryan C. Fields, Richard A. Flavell Advancing Precision Oncology in a Humanized, Fully Autologous Mouse Model 
Brigham and Women's Hospital Christopher French, Derin Keskin, Geoffrey Shapiro Genetically engineered mouse model to improve therapy of NUT carcinoma
MD Anderson Cancer Center  Giannicola Genovese Investigation of the Role of Epithelial-Mesenchymal Plasticity in Renal Cell Carcinoma 
Cincinnati Children’s Hospital Leighton H. Grimes, Stephanie Halene

Modeling Myelodysplasia 

Cedars-Sinai Medical Center Jlenia Guarnerio Comparative Modeling of Sarcoma Microenvironments for the Discovery of Biomarkers and Tumor Vulnerabilities 
Dana-Farber Cancer Institute Kevin Haigis

Mouse Models of Kras-Mutant Colorectal Cancer 

University of California Los Angeles Anthony Heaney Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery
Jackson Laboratory Vishnu Hosur Site-specific Integration of Large (10-100 kb) DNA Constructs into the Mouse Genome and Human Induced Pluripotent Stem Cells Using the Cas9-Bxb1 Integrase Toolbox
Johns Hopkins University Chien-Fu Hung, Richard Bruce Roden Mouse Modeling of HPV Infection 
Massachusetts Institute of Technology Tyler E. Jacks Development of Novel Metastatic Mouse Models that Recapitulate the Major Immune Contexts of Human Colon Cancer 
Yale University Nikhil Joshi Developing Translationally-Relevant Genetically Engineered Mouse Models of Lung Adenocarcinoma for Investigations in Cancer Immunology 
Weill Medical College of Cornell Univ Tan A Ince Culture of tumor versus normal cells
Wayne State University Jennifer Jacob, Benjamin Kidder Defining Cancer Intervention Targets by Functional Genomics Analysis of Outbred F1 Mice
University of California, San Diego Michael Karin A new mouse model for studying the pathogenesis and immunobiology of intrahepatic cholangiocarcinoma and improving its immunotherapy
University of California, San Diego Michael Karin Highly Penetrant and Immunogenic Mouse Models of Non-Viral HCC that are Suitable for Evaluation of Immune Checkpoint Inhibitors 
Univ of Massachusetts Medical School Worcester Elinor Karlsson Transforming family dogs into a powerful and accessible model for human cancer
Univ of Massachusetts Medical School Worcester Elinor Karlsson, Cheryl A London Leveraging canine spontaneous cancer to optimize the power of blood biopsy
University of Wisconsin-Madison Randall Kimple Improving the translational value of head and neck 
University of Texas MD Anderson Frederick F Lang A Novel Adenoviral-Permissive, Immunocompetent Hamster Model to Evaluate Oncolytic Adenoviral Therapy for Glioblastoma
Uppsala University Kerstin Lindblad-Toh Enhancing the Dog as a Model for Human Cancers: From Genome Sequence Towards Clinical Trials 
Baylor College of Medicine Yi Li, Xiang Zhang Next Generation Rat Models of ER+ Breast Cancer
Baylor College of Medicine Yong Li Optimizing Syngeneic Mouse Models to Target Mutant p53
Georgetown University Xuefeng Liu Conditionally Reprogrammed Cell Model for Castration-Resistant Prostate Cancer (CRPC) 
Memorial Sloan Kettering Cancer Center Scott W. Lowe Rapid and Flexible Precision Oncology Mouse Models of Epithelial Malignancies 
Washington University Jeffrey Magee, Jeffery KLCO Cross-species development and credentialing of pediatric AML models
University of Alabama at Birmingham Christopher Ryan Miller, Frank Furnari, Donald O'Rourke Credentialing next-generation human glioma models for precision therapeutics
MD Anderson Cancer Center Anirban Maitra Translational Applications in an Animal Model of Pancreatic Cystic Neoplasm and Cancer 
University of California Los Angeles David A. Nathanson, Thomas G. Graeber Mammalian Models for Integrated Metabolic and Molecular Profiling of Malignant Glioma 
Weill Medical College of Cornell University David Nowak Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis
University of Pittsburgh Steffi Oesterreich, Andrian V. Lee Credentialing Models of Invasive Lobular Breast Cancer for Translational Research 
H. Lee Moffitt Cancer Center Eric Padron Developing and Credentialing Patient-Derived Xenograft Models to Advance Therapeutic Approaches for Chronic Myelomonocytic Leukemia 
University of California at Davis Robert B Rebhun Clinical, molecular, and immune characterization of naturally occurring osteosarcoma in dogs
University of California, San Francisco Susanna Rosi, Nalin Gupta Myeloid Cells and Radiation-Induced Memory Deficits in Rodent Glioma Model: Sex and Age Effects 
Roswell Park Cancer Institute Mukund Seshadri Radiogenomic Credentialing of Head and Neck Cancer Models 
Baylor College of Medicine  Lanlan Shen Epigenetically Engineered Mouse Model for Lung Cancer Therapy
Memorial Sloan Kettering Cancer Center Jesse Joshua Smith Expansion of Tumoroid Models for Precise Treatment of the Rectal Cancer Patient 
Duke University Joshua Clair Snyder

Visualizing Tumor Heterogeneity in an Immune Intact and Autochthonous Mouse Model of Breast Cancer 

University of California, San Francisco Eric Alejandro Sweet-Cordero, David H. Haussler Development of Advanced Preclinical Models for Pediatric Solid Tumors 
University Of Alabama at Birmingham Deeann Wallis-Schultz, Robert Kesterson Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system
Johns Hopkins University Tzyy-Choou Wu

Development of Novel Spontaneous HPV Cervicovaginal Carcinoma Models for Cancer Immunotherapy 

University of Pennsylvania Xiaowei Xu, Meenhard Herlyn Gamma delta T cell based melanoma therapies
University of Massachusetts Medical School of Worcester Wen Xue In vivo prime editing for precision cancer mouse models
Cleveland Clinic Lerner College of Medicine Jianjun Zhao New mouse model of cisplatin-induced AKI and development of prevention therapy
University of Georgia Shaying Zhao, William Hildebrand Canine MHC-I genotyping and tumor specific neoantigen determination
UT Southwestern Medical Center Hao Zhu

Improving Hepatocellular Carcinoma Mouse Modeling by Understanding the Malignant Potential and Biology of Liver Cell Subpopulations 

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