Institution |
Principal Investigator(s) |
Project Title |
Baylor College of Medicine |
Yong Li |
Optimizing syngeneic mouse models to target mutant p53 |
Baylor College of Medicine |
Lanlan Shen |
Epigenetically engineered mouse model for lung cancer therapy |
Baylor College of Medicine |
Xiang Zhang, Yi Li |
Next generation rat models of ER+ breast cancer |
Beth Israel Deaconess Medical Center |
Vassiliki A. Boussiotis, Alain Charest, Roel Verhaak |
Understanding the cellular and functional changes in the immune tumor microenvironment of glioblastoma during progression and treatments |
Brigham and Women's Hospital |
Derin B. Keskin, Christopher A. French, Geoffrey I. Shapiro |
Genetically engineered mouse model to improve therapy of NUT carcinoma |
Cedars Sinai Medical Center |
Jlenia Guarnerio |
Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities |
Cincinnati Children's Hospital Medical Center |
Stephanie Halene, H. Leighton Grimes |
Modeling myelodysplasia |
Cleveland Clinic Lerner College of Medicine |
Jianjun Zhao |
New mouse model of cisplatin-induced AKI and development of prevention therapy |
Dana-Farber Cancer Institute |
Kevin Haigis |
Mouse models of Kras-mutant colorectal cancer |
Duke University |
Ming Chen |
Engineering large chromosomal deletions in mice to advance precision oncology |
Duke University |
Joshua C. Snyder |
Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer |
Emory University |
Peter Canoll, Nicholas M. Boulis |
Lentiviral-induced swine model of spinal cord glioma |
Jackson Laboratory |
Vishnu Hosur |
Site-specific integration of large (10-100 kb) DNA constructs into the mouse genome and human induced pluripotent stem cells using the Cas9-Bxb1 integrase toolbox |
Johns Hopkins University |
Richard B. Roden, Chien-Fu Hung |
Mouse modeling of HPV infection |
Massachusetts Institute of Technology |
Jesse S. Boehm |
Rapid ex vivo biosensor cultures to assess dependencies in gastroesophageal cancer |
Mayo Clinic, Scottsdale |
Marta Chesi, Peter L. Bergsagel |
Preclinical optimization of BCMA directed T cell therapy |
MD Anderson Cancer Center |
Giannicola Genovese |
Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma |
MD Anderson Cancer Center |
Frederick F. Lang |
A novel adenoviral-permissive, immunocompetent hamster model to evaluate oncolytic adenoviral therapy for glioblastoma |
Memorial Sloan-Kettering Cancer Center |
Scott W. Lowe |
Rapid and flexible precision oncology mouse models of epithelial malignancies epithelial malignancies |
Memorial Sloan-Kettering Cancer Center |
Jesse J. Smith |
Expansion of tumoroid models for precise treatment of the rectal cancer patient |
Northwestern University |
Daniel J. Brat |
Modeling the glioblastoma microenvironment to uncover progression mechanisms and therapeutic targets |
Rockefeller University |
Stylianos Bournazos |
Novel transgenic mouse models addressing outstanding translational barriers in antibody-based therapeutics |
Roswell Park Comprehensive Cancer Center |
Mukund Seshadri |
Radiogenomic credentialing of head and neck cancer models |
Tufts Medical Center |
Iris Z. Jaffe, Cheryl A. London |
Credentialing a cross-species platform to investigate cancer therapy-associated cardiovascular toxicity |
University of Alabama, Birmingham |
Robert A. Kesterson, Deeann Wallis Schultz |
Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system |
University of Alabama, Birmingham |
Donald M. O'Rourke, Christopher R. Miller, Frank Furnari |
Credentialing next-generation human glioma models for precision therapeutics |
University of California, Davis |
Robert B. Rebhun |
Clinical, molecular, and immune characterization of naturally occurring osteosarcoma in dogs |
University of California, Los Angeles |
Anthony P. Heaney |
Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery |
University of California, San Diego |
Michael Karin |
A new mouse model for studying the pathogenesis and immunobiology of intrahepatic cholangiocarcinoma and improving its immunotherapy |
University of California, San Diego |
Michael Karin |
Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors |
University of California, San Francisco |
Allan Balmain, Rosemary J. Akhurst |
A network approach to interrogate cellular plasticity and drug resistance in cancer |
University of California, San Francisco |
Nalin Gupta |
Myeloid cells and radiation-induced memory deficits in rodent glioma model: sex and age effects |
University of California, San Francisco |
Eric Alejandro Sweet Cordero, Olena Morozova Vaske |
Development of advanced preclinical models for pediatric solid tumors |
University of Colorado Denver |
Patricia Ernst, Terry J. Fry |
Escape from CAR T surveillance through lineage plasticity |
University of Georgia |
William Hildebrand, Shaying Zhao |
Canine MHC-I genotyping and tumor specific neoantigen determination |
University of Massachusetts Medical School Worcester |
Elinor Karlsson, Cheryl A. London |
Leveraging canine spontaneous cancer to optimize the power of blood biopsy |
University of Massachusetts Medical School Worcester |
Wen Xue |
In vivo prime editing for precision cancer mouse models |
University of Pennsylvania |
Zev Ari Binder |
Development and validation of an autologous mouse model for the study of immune interactions with glioblastoma |
University of Pennsylvania |
Xiaowei Xu, Meenhard F. Herlyn |
Gamma delta T cell based melanoma therapies |
University of Pittsburgh |
Steffi Oesterreich, Adrian V. Lee |
Credentialing models of invasive lobular breast cancer for translational research |
University of Wisconsin, Madison |
Randall J. Kimple |
Improving the translational value of head and neck cancer patient-in-mouse models |
University of Texas Southwestern Medical Center |
Ling Cai, Shidan Wang |
Construction of a lung cancer preclinical model cross-comparison platform |
University of Texas Southwestern Medical Center |
Diego H. Castrillon |
Polymerase epsilon-based mouse and derived organoid models of intestinal cancer |
University of Texas Southwestern Medical Center |
Diego H. Castrillon |
Polymerase-mediated ultramutagenesis and carcinogenesis in mice |
University of Texas Southwestern Medical Center |
Hao Zhu |
Improving hepatocellular carcinoma mouse modeling by understanding the malignant potential and biology of liver cell subpopulations |
Washington University in St. Louis |
Richard A. Flavell, Ryan C. Fields |
Advancing precision oncology in a humanized, fully autologous mouse model |
Washington University in St. Louis |
Jeffrey A. Magee, Jeffery M. Klco |
Cross-species development and credentialing of pediatric AML models |
Wayne State University |
Jennifer B. Jacob, Benjamin L. Kidder |
Defining cancer intervention targets by functional genomics analysis of outbred F1 mice |
Weill Cornell Medicine |
Lukas E. Dow |
In vivo base editing for precision oncology models |
Weill Cornell Medicine |
Tan A. Ince |
Culture of tumor versus normal cells |
Weill Cornell Medicine |
Dawid G. Nowak |
Novel mouse models for quantitative understanding of baseline and therapy-driven evolution of prostate cancer metastasis |
Yale University |
Nikhil Joshi |
Developing translationally-relevant genetically engineered mouse models of lung adenocarcinoma for investigations in cancer immunology |