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Cancer Currents: An NCI Cancer Research Blog

A blog featuring news and research updates from the National Cancer Institute.

An illustrated banner to represent NCI's Cancer Currents research news blog. The design features interconnected scenes: a patient receiving care, a researcher in a lab, a tumor model, a laptop and mobile device displaying research articles, fitness activity, a clinical setting, and a researcher giving a scientific presentation. The background showcases rolling hills and abstract buildings.
  • A factoid illustrating the 13% to 23% increase in parents safety concerns.
    • By Nadia Jaber

    Despite consistent evidence that HPV vaccines are safe and effective, a new study shows that more parents are citing concerns about their safety. Researchers cautioned that efforts are needed to counter this trend and improve vaccination rates.

  • An illustration of trastuzumab deruxtecan's mechanism of action
    • By Elia Ben-Ari

    In people with metastatic HER2-positive breast cancer, the targeted drug trastuzumab deruxtecan (Enhertu) markedly lengthened progression-free survival compared with trastuzumab emtansine (Kadcycla), new study results show.

  • Bethany ross from the back with a "survivor neuroendocrine cancer" shirt
    • By Edward Winstead

    New treatments are helping more people with advanced or metastatic cancer live longer. At a recent NCI conference, survivors and researchers came together to discuss how to better address the needs of those living with metastatic cancer.

  • Close-up view of a medical procedure being performed on a person’s hand, showing a healthcare provider using surgical tools while another assists with a cotton swab.
    • By Linda Wang

    Trial results show patients who received the immunotherapy pembrolizumab (Keytruda) after surgery to remove high-risk stage II melanomas were less likely to have the cancer come back than those who received no treatment after surgery.

  • graphic of the mode of action of CDK4/6 inhibitors
    • By Carmen Phillips

    In a large clinical trial, women with HR-positive, HER2-negative metastatic breast cancer treated with ribociclib (Kisqali) and letrozole (Femara) as their initial treatment lived approximately 1 year longer than women treated with letrozole only.

  • Side by side illustrations of breast-conserving surgery and a simple mastectomy.
    • By Edward Winstead

    Women with early-stage breast cancer who had one or both breasts surgically removed (a unilateral or bilateral mastectomy) had lower scores on a quality-of-life survey than women who had breast-conserving surgery, a new study has found.

  • A medical professional performs an ultrasound on a patient's neck to examine the thyroid gland.
    • By Sharon Reynolds

    Women are far more likely than men to be diagnosed with small thyroid cancers that probably would have never caused problems during their lifetime, a new study finds. The results may help explain why thyroid cancer seems to be more common in women.

  • A process called spectral karyotyping shows widespread aneuploidy in a cell line of lung cancer.
    • By Nadia Jaber

    Aneuploidy—when cells have too many or too few chromosomes—is common in cancer cells, but scientists didn’t know why. Two new studies suggest that aneuploidy helps the cells survive treatments like chemotherapy and targeted therapies.

  • Diagram illustrates how HIF (Hypoxia-Inducible Factor) proteins respond to oxygen levels. Under hypoxia, HIF-1α and HIF-2α move to the nucleus, forming a complex at the HRE (Hypoxia-Responsive Element) site. HIF-2α inhibitors can block this process, affecting gene expression.
    • By Linda Wang

    FDA has approved belzutifan (Welireg) to treat adults with von Hippel-Lindau disease (VHL) who have tumors of the kidney, brain, nervous system, or pancreas. The drug may help these patients avoid or delay surgery by shrinking their tumors.

  • NCI Director Dr. Norman E. Sharpless with two campers
    • By Norman E. Sharpless, M.D.

    NCI Director Dr. Ned Sharpless discusses progress against childhood cancers, like CAR T-cell therapy and collecting more comprehensive data on children and adolescents with cancer, and the need to better address disparities in childhood cancer.

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