Treatment - Cancer Currents Blog
Cancer treatment related news, with context from leading experts. Includes articles on new therapies, treatment side effects, and important trends in treatment-related research.
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Anthrax Toxin-Based Cancer Therapy Targets Tumor Blood VesselsA therapy that uses the anthrax toxin selectively targets blood vessels that feed tumors and support their growth and spread, researchers have found.
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Extended Adjuvant Therapy Beneficial for Some Women with Breast CancerResults from a recent clinical trial showed that extending adjuvant therapy with an aromatase inhibitor to 10 years after initial treatment can have important benefits for postmenopausal women with early-stage hormone receptor–positive breast cancer.
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Early-Stage Cancer Trials Support Promise of Precision Medicine, ImmunotherapyEncouraging findings from several early-stage clinical trials featured at the 2016 American Society of Clinical Oncology annual meeting support the promise of precision medicine and immunotherapy.
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Trials Produce Practice-Changing Results for Brain CancerResults from two clinical trials show that treating patients with the chemotherapy drug temozolomide in addition to radiation therapy increased overall and progression-free survival.
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Patient-Derived Antibody Appears to Selectively Target Tumor Cells, Spur Immune AttackThe CFH antibodies killed tumor cells in cell lines of several cancer types and slowed tumor growth in mouse models of brain and lung cancer, without evidence of side effects.
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Colorectal Cancer Survival Linked to Primary Tumor LocationA blog post on a study showing that in patients with metastatic colorectal cancer, the location in the colon where the tumor originated appears to strongly influence how long patients live.
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New Treatment Target Identified for Diffuse Large B-Cell LymphomaNCI researchers have identified new therapeutic targets for diffuse large B-cell lymphoma. Drugs that hit these targets are under clinical development and the researchers hope to begin testing them in clinical trials of patients with DLBCL.
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Targeted Photoimmunotherapy Approach for Cancer Moves ForwardTwo new studies from NCI researchers add to growing evidence of the promise of a novel type of cancer immunotherapy that uses infrared light to activate rapid and selective killing of cancer cells.
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New Treatment Target Identified for Key Prostate Cancer DriverResearchers have identified a potential alternative approach to blocking a key molecular driver of an advanced form of prostate cancer, called androgen-independent or castration-resistant prostate cancer.
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Pembrolizumab Shows Promise in Patients with Rare Form of Skin CancerIn a small clinical trial, more than half of the patients with an aggressive form of skin cancer called Merkel cell carcinoma responded to the immunotherapy drug pembrolizumab.
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Nanoparticle Generator Slips Chemotherapy Past Tumor Cells’ Protective BarriersResearchers have developed a new injectable nanoparticle-generating technology that can deliver a cancer drug to the nucleus of metastatic breast cancer cells.
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Sunitinib and Sorafenib Ineffective as Adjuvant Therapies for Kidney CancerResults from a recent clinical trial show that post-surgical therapy with two anti-angiogenesis drugs does not improve progression-free survival for patients with kidney cancer and may cause serious side effects.
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Drug Combination Shrinks Duodenal Polyps in People with Familial Adenomatous PolyposisIn a small clinical trial of people with an inherited condition that greatly increases gastrointestinal cancer risk, a two-drug combination shrank precancerous lesions in the duodenum.
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Blocking Calcium Transfer May Selectively Kill Cancer CellsA new study shows that blocking the transfer of calcium ions (Ca2+) into mitochondria is toxic to cancer cells and impairs growth of tumors in mice, while sparing normal cells.
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New Strategy for Treating Advanced Ovarian Cancer Shows Promise in MiceThe use of a protein fragment to stimulate cells in the tumor microenvironment against cancer shows promise in animal models of metastatic ovarian cancer.
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Keeping Pace: How New Data Can Affect Ongoing Clinical TrialsResearch results sometimes outrace the design of an ongoing clinical trial and the trial has to be recalibrated to include newer treatments, according to NCI’s Dr. Jo Anne Zujewski.
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Novel Strategy Isolates Immune Cells in the Blood that Recognize MelanomaNCI scientists have developed a novel strategy for identifying immune cells circulating in the blood that recognize specific proteins on tumor cells, a finding they believe may have potential implications for immune-based therapies.
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Missed Radiation Therapy Sessions Increase Risk of Cancer RecurrencePatients who miss radiation therapy sessions during cancer treatment have an increased risk of their disease returning, even if they eventually complete their course of radiation treatment, according to a new study.
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Novel Treatment Approach Shrinks Ovarian Tumors in MiceResearchers have developed a new approach for treating tumors that express mutant versions of the p53 protein, which are present in more than half of all cancers, including an aggressive and common subtype of ovarian cancer.
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Two Drugs Show Efficacy against Common Form of LeukemiaReports from early-stage trials of two new oral drugs provide hope for patients with high-risk chronic lymphocytic leukemia.