NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,351 terms related to cancer and medicine.

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von Hippel-Lindau gene
(von HIH-pul-LIN-dow jeen)
A gene that makes the von Hippel-Lindau (VHL) protein, which helps control cell growth, cell division, and other important cell functions. Changed forms of the von Hippel-Lindau gene may increase the growth of cells, including abnormal cells. This mutated gene has been found in nearly all patients with an inherited condition called VHL syndrome. VHL syndrome can cause kidney cancer and tumors of the brain, spinal cord, eye, ear, adrenal glands, pancreas, or other parts of the body. The von Hippel-Lindau gene is a type of tumor suppressor gene. Also called VHL gene.