NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,371 terms related to cancer and medicine.

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tumor protein p53 gene
(TOO-mer PROH-teen ... jeen)
A gene that makes a protein called tumor protein p53. This protein is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. It helps keep abnormal cells, including cancer cells, from growing. Mutations (changes) in the tumor protein p53 gene may cause cancer cells to grow and spread in the body. These changes have been found in a genetic condition called Li-Fraumeni syndrome and in many types of cancer. The tumor protein p53 gene is a type of tumor suppressor gene. Also called p53 gene and TP53 gene.