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MAP

A rare, inherited disorder in which multiple polyps (abnormal growths) form on the inner walls of the colon and rectum. People with MAP usually develop fewer than 100 colon polyps, and polyps may also occur in the stomach and small intestine. People with MAP have a high risk of developing colorectal cancer. They may also be at increased risk of developing cancers of the stomach, small intestine, ovary, endometrium, bladder, liver, thyroid, and skin. MAP is caused by mutations (changes) in the MUTYH gene that are inherited in an autosomal recessive manner. It is a type of hereditary cancer syndrome. Also called MUTYH-associated polyposis.
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Drawing showing an autosomal recessive inheritance pattern between a father, mother, and their four children: an unaffected father (carrier) with a mutated gene and a normal gene on a chromosome pair; an unaffected mother (carrier) with a mutated gene and a normal gene; an unaffected daughter with two normal genes; an unaffected son (carrier) with a mutated gene and a normal gene; an unaffected daughter (carrier) with a mutated gene and a normal gene; and an affected son with two mutated genes.Enlarge this image in new window
Autosomal recessive inheritance is a way a genetic trait or condition can be passed down from parent to child. A genetic condition can occur when the child inherits one copy of a mutated (changed) gene from each parent. The parents of a child with an autosomal recessive condition usually do not have the condition. Unaffected parents are called carriers because they each carry one copy of the mutated gene and can pass it to their children.
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