NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,573 terms related to cancer and medicine.

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MDX-010
A drug used with nivolumab in adults and in children aged 12 years and older to treat a certain type of colorectal cancer that has mutations (changes) in genes involved in DNA repair. It is also used with nivolumab in some patients to treat renal cell carcinoma and hepatocellular carcinoma. MDX-010 is also used alone in some patients to treat melanoma. It is also being studied in the treatment of other types of cancer. MDX-010 binds to a protein called CTLA-4, which is found on T cells (a type of white blood cell). MDX-010 may block CTLA-4 and help the immune system kill cancer cells. It is a type of monoclonal antibody and a type of immune checkpoint inhibitor. Also called ipilimumab and Yervoy.