Skip to main content
An official website of the United States government
Español
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

promyelocytic leukemia gene

(proh-MY-eh-loh-SIH-tik loo-KEE-mee-uh jeen)
A gene that makes a protein that helps control cell growth and cell division. Mutations (changes) in the promyelocytic leukemia gene can occur when a piece of the chromosome containing the promyelocytic leukemia gene breaks off and joins with a gene called RARA on another chromosome. These changes may cause too many immature white blood cells to build up in the blood and bone marrow. This can lead to an aggressive (fast-growing) type of acute myeloid leukemia called acute promyelocytic leukemia. The promyelocytic leukemia gene is a type of tumor suppressor gene. Also called PML gene.
Search NCI's Dictionary of Cancer Terms