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unclassified variant

(un-KLA-sih-fide VAYR-ee-unt)
A change in a gene’s DNA sequence that has an unknown effect on a person’s health. There is usually not enough information about an unclassified variant to know whether it increases a person’s risk of developing a disease, such as cancer. Also called variant of uncertain significance, variant of unknown significance, and VUS.
Search NCI's Dictionary of Cancer Terms