NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 8,107 terms related to cancer and medicine.

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PKC412
A drug used with cytarabine and daunorubicin to treat acute myeloid leukemia (AML) that has a mutated (changed) form of a gene called FLT3. It is also used to treat mast cell leukemia (a very rare type of leukemia) and systemic mastocytosis (a rare condition in which there are too many mast cells in the body). It is also being studied in the treatment of other types of cancer. PKC412 blocks certain proteins, which may help keep cancer cells from growing and may kill them. It may also prevent the growth of new blood vessels that tumors need to grow. PKC412 is a type of protein kinase inhibitor and a type of antiangiogenesis agent. Also called midostaurin, N-benzoyl-staurosporine, and Rydapt.