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Gastrointestinal Steering Committee

The NCI Gastrointestinal Cancer Steering Committee (GISC) was established in January 2006. At monthly meetings, the GISC addresses the design, prioritization, and evaluation of concepts for phase 2 and phase 3 clinical trials in adult gastrointestinal cancers. View the GISC member roster.

Strategic Priorities

  • GISC Strategic Priorities were formulated with the goal that the majority of submitted concepts would align with these established priorities. They address areas of unmet clinical need, important unanswered clinical questions, and potential new approaches to disease treatment.

Task Forces

  • Task forces were established to discuss concepts and make recommendations for clinical trial planning meetings in their disease subtype:
    • esophagogastric
    • colon
    • hepatobiliary
    • neuroendocrine tumors
    • pancreas
    • rectal-anal
  • The Colon and Rectal-Anal task forces met in June 2018 to develop guidelines for research in the use of circulating tumor DNA in the care and management of colorectal cancer. Read the consensus recommendations.

Clinical Trials Planning Meetings (CTPMs)

CTPMs are held periodically and focus on specific clinical trial-related topics. The following are important, recent GISC CTPMs:

  • Neuroendocrine Tumor PRRT CTPM 
    The NCI Neuroendocrine Tumor Task Force held a CTPM in March 2021 to identify clinical trial strategies to help define the treatment of patients with neuroendocrine tumors in the era of Peptide Receptor Radionuclide Therapy (PRRT). Read the executive summary.
  • Gastroesophageal Carcinoma Immuno-Oncology CTPM 
    The NCI Esophagogastric Task Force held a CTPM in May 2018 to develop strategies for the incorporation of immuno-oncology therapeutic approaches for gastric and esophageal cancer and to identify clinical trial designs to address this unmet need. Read the executive summary.
  • Rectal-Anal and Colon Cancers CTPM
    In January 2011, the NCI Colon and Rectal-Anal Task Forces held a CTPM to develop a blueprint for the next generation of clinical trials for patients with colorectal cancer. Read the executive summary.


For more information, contact Wolf Lindwasser, Ph.D. at