Cancer Currents: An NCI Cancer Research Blog
A blog featuring news and research updates from the National Cancer Institute. Learn more about Cancer Currents.
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Program Helps Medically Underserved, Minority Cancer Survivors Be More ActiveA program in Texas helped minority and medically underserved cancer survivors get much more physical activity, according to a new study. Participants also reported improved physical functioning and quality of life.
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Tumor Signatures May Help Explain Global Differences in Kidney Cancer RatesBy analyzing patterns of DNA mutations in kidney cancers from people around the world, researchers have discovered new clues about possible causes of the disease. Identifying these mutational signatures might lead to strategies for preventing kidney cancer.
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How Breast Cancer Risk Assessment Tools WorkDrs. Ruth Pfeiffer and Peter Kraft of NCI’s Division of Cancer Epidemiology and Genetics discuss how breast cancer risk assessment tools are created and how people can use them to understand and manage their risk.
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Durvalumab Extends Lives of People with Early-Stage Small Cell Lung CancerThe immunotherapy drug durvalumab (Imfinzi) can help people with early-stage small cell lung cancer live longer, results from a large clinical trial show. Three years after starting treatment, nearly 60% of people who received the drug were still alive.
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Experimental mRNA Vaccine Hints at Potential Against GlioblastomaRecent results from several small clinical trials have suggested it may be possible to develop an effective immunotherapy for glioblastoma. Among them are findings from a four-patient trial testing a unique type of mRNA cancer vaccine.
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Anal Cancer Advances Open Door to Screening and PreventionA recent study showed that removing precancerous anal lesions can prevent anal cancer. Scientists are now studying how best to screen people at the high risk of anal cancer, including those with HIV, for these lesions.
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Spurred by Survivors, Researchers Are Revisiting Cancer Drug DosesWhen it comes to cancer drugs, researchers are moving away from a paradigm called the maximum tolerated dose. Instead, they’re focusing more on identifying doses that produce fewer side effects but are still effective against a person’s cancer.
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Leading Change in Cancer Clinical Research, Because Our Patients Can’t WaitReshaping the cancer clinical trials infrastructure to overcome key bottlenecks will involve embracing technology and collaboration, and inviting innovation, explain NCI Director Dr. W. Kimryn Rathmell and NCI Special Advisor Dr. Shaalan Beg.
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Tovorafenib Approved for Some Children with Low-Grade GliomaFDA has granted an accelerated approval to tovorafenib (Ojemda) for kids and teens who have low-grade glioma with changes in the BRAF gene. In a small clinical trial, the drug shrank or completely eliminated tumors in nearly 70% of patients.
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Pembrolizumab Is First Adjuvant Therapy to Improve Overall Survival in Kidney CancerIn a large clinical trial, treatment with pembrolizumab after surgery helped people with kidney cancer live longer than those who got a placebo and standard monitoring. The findings mark the first time an adjuvant treatment for kidney cancer has improved survival.
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New Approach May Help People with Cancer Better Manage Depression, Pain, and FatigueAssessing and offering people with cancer stepped collaborative care may help better manage symptoms of depression, pain, and fatigue than the standard referral to providers for treatment, according to a recent study.
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Blood Test Accurately Detects Early-Stage Pancreatic CancerIn a new study involving nearly 1,000 people, a liquid biopsy accurately detected early- and late-stage pancreatic cancer. When paired with a test for the protein CA19-9, the combination accurately identified 97% of people with early-stage disease.
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Alectinib Approved as an Adjuvant Treatment for Lung CancerFDA has approved alectinib (Alecensa) as adjuvant therapy for people with lung cancer who have ALK-positive tumors. In a clinical trial, alectinib helped people live longer after surgery without their cancer returning than chemotherapy.
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FDA Approves Trastuzumab Deruxtecan for Any HER2-Positive Solid CancerTrastuzumab deruxtecan (Enhertu) can now be used to treat any advanced solid cancer that produces high levels of the protein HER2 (HER2-positive tumors). FDA’s accelerated approval was based on findings from three clinical trials.
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Q&A: Learning About the Cancer Care Challenges LGBTQ+ People FaceGwendolyn Quinn, Ph.D., a health psychologist at NYU Langone Health Perlmutter Cancer Center, discusses the challenges faced by sexual and gender minority people being treated for cancer and ways to address them.
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LGBTQ+ Voices: Listening to Sexual and Gender Minority People Affected by CancerLGBTQ+ people, also known as sexual and gender minorities (SGM), with cancer may face challenges that non-SGM people do not face. The breadth and depth of these disparities aren't well known, but there’s growing research on the challenges this diverse group faces.
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Approval of Elahere Expands Treatment Options for Some Advanced Ovarian CancersFDA approved mirvetuximab soravtansine-gynx (Elahere) to treat people with advanced, platinum-resistant ovarian cancer whose tumors overproduce a protein called FR-α. The full approval was based on the results of a large, randomized trial called MIRASOL, which showed Elahere improved survival for these people.
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Scientists Link a Single Type of Bacteria to Colorectal CancerNCI-funded researchers have pinpointed a single type of the bacterium F. nucleatum that appears to fuel the development and growth of colorectal cancer. In mice, the bacterium, Fna C2, appeared to cause more adenomas to form in the large intestine and it was often found in human tumor samples.
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Studies Assess Impact of Cancer Risk-Reduction Measures for People with BRCA ChangesFor women with inherited changes in the BRCA1 or BRCA2 genes, regular MRI scans and undergoing a surgery called a salpingo-oophorectomy appear to lower their chances of dying from breast and ovarian cancer, according to results from two studies.
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New on NCI’s Websites for April 2024NCI periodically provides updates on new websites and other online content of interest to the cancer community. See selected content that has been added as of April 2024.