FDA-Approved Drugs for Childhood Cancer
The Food and Drug Administration has approved more than two dozen drugs to treat childhood cancers. Data from NCI-sponsored clinical trials were used to support the approvals of several of these drugs (marked by asterisks).
Drug Name | Childhood Cancer |
---|---|
Asparaginase Erwinia chrysanthemi* | Acute lymphoblastic leukemia |
Avelumab | Merkel cell carcinoma |
Blinatumomab | Recurrent or refractory B-cell acute lymphoblastic leukemia |
Calaspargase Pegol-mknl* | Acute lymphoblastic leukemia |
Clofarabine* | Acute lymphoblastic leukemia |
Cyclophosphamide | Acute lymphoblastic leukemia |
Cytarabine | Acute leukemia Meningeal leukemia Chronic myelogenous leukemia |
Dactinomycin |
Ewing sarcoma Wilms tumor Metastatic nonseminomatous testicular cancer |
Dasatinib* | Philadelphia chromosome-positive chronic myelogenous leukemia |
Daunorubicin Hydrochloride | Acute lymphoblastic leukemia |
Dinutuximab (monoclonal antibody ch14.18)* | Neuroblastoma |
Everolimus | Subependymal giant cell astrocytoma |
Gemtuzumab Ozogamicin | CD33-positive acute myeloid leukemia |
Imatinib* |
Chronic myelogenous leukemia |
Iobenguane I-131 |
Malignant pheochromocytoma Paraganglioma |
Ipilimumab |
Melanoma Mismatch repair-deficient and microsatellite instability-high colorectal cancer |
Larotrectinib* | Solid tumors with an NTRK gene fusion |
Mercaptopurine | Acute lymphoblastic leukemia |
Nelarabine* |
T-cell acute lymphoblastic leukemia T-cell lymphoblastic lymphoma |
Nilotinib | Philadelphia chromosome-positive chronic myelogenous leukemia |
Nivolumab | Mismatch repair-deficient and microsatellite instability-high colorectal cancer |
Pegaspargase* | Acute lymphoblastic leukemia |
Pembrolizumab* |
Refractory classic Hodgkin lymphoma Mismatch repair-deficient and microsatellite instability-high solid tumors Recurrent, locally advanced, or metastatic Merkel cell carcinoma primary mediastinal large B-cell lymphoma |
Procarbazine Hydrochloride* | Hodgkin lymphoma |
Tagraxofusp-erzs | Blastic plasmacytoid dendritic cell neoplasm |
Teniposide (discontinued) | Acute lymphoblastic leukemia |
Tisagenlecleucel* | Refractory B-cell acute lymphoblastic leukemia |
Vincristine Sulfate |
Acute leukemia Hodgkin lymphoma Neuroblastoma Non-Hodgkin lymphoma Rhabdomyosarcoma Wilms tumor |