NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 8,208 terms related to cancer and medicine.

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5 results found for: antibody
antibody
(AN-tee-BAH-dee)
A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen. An antibody is a type of immunoglobulin.
antibody therapy
(AN-tee-BAH-dee THAYR-uh-pee)
Treatment that uses antibodies to help the body fight cancer, infection, or other diseases. Antibodies are proteins made by the immune system that bind to specific markers on cells or tissues. Monoclonal antibodies are a type of antibody made in the laboratory that can be used in diagnosis or treatment. In cancer treatment, monoclonal antibodies may kill cancer cells directly, they may block development of tumor blood vessels, or they may help the immune system kill cancer cells.
antibody-dependent cell-mediated cytotoxicity
(AN-tee-BAH-dee-deh-PEN-dent sel-MEE-dee-AY-ted SY-toh-tok-SIH-sih-tee)
A type of immune reaction in which a target cell or microbe is coated with antibodies and killed by certain types of white blood cells. The white blood cells bind to the antibodies and release substances that kill the target cells or microbes. Also called ADCC and antibody-dependent cellular cytotoxicity.
antibody-dependent cellular cytotoxicity
(AN-tee-BAH-dee-deh-PEN-dent SEL-yoo-ler SY-toh-tok-SIH-sih-tee)
A type of immune reaction in which a target cell or microbe is coated with antibodies and killed by certain types of white blood cells. The white blood cells bind to the antibodies and release substances that kill the target cells or microbes. Also called ADCC and antibody-dependent cell-mediated cytotoxicity.
antibody-drug conjugate
(AN-tee-BAH-dee ... KON-jih-gut)
A substance made up of a monoclonal antibody chemically linked to a drug. The monoclonal antibody binds to specific proteins or receptors found on certain types of cells, including cancer cells. The linked drug enters these cells and kills them without harming other cells. Some antibody-drug conjugates are used to treat cancer. Also called ADC.